Altered Gene Can Increase Risk of Schizophrenia: A potential point of entry for drug therapy

News Type: Event — Seeded on Wed Apr 29, 2009 5:40 PM EDT

Article Source: Rutgers

science, brain, drug, dna, genetics, therapy, psychiatry, gene, schizophrenia

Rutgers geneticist Linda Brzustowicz and her colleagues have identified a specific DNA change that is likely to increase risk for developing schizophrenia in some people. It provides a potential mechanism that may be a point of entry for drug therapy, consistent with the growing trend of personalized medicine.

The research findings are reported in the April issue of the American Journal of Psychiatry (AJP). An accompanying editorial highlights the significance of this work.

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{"commentId":6793566,"authorDomain":"agila"}

agila

Brzustowicz, a professor of genetics at Rutgers, The State University of New Jersey, and board-certified psychiatrist, said that the research has demonstrated a functional DNA change that increases gene expression. This conclusion is based on its presence in the genes of a Canadian study population of 24 families where multiple individuals had been diagnosed with schizophrenia. The gene in question, NOS1AP, previously known as CAPON, is one which Brzustowicz has been studying for six years.

{"commentId":6793566,"threadId":"566572","contentId":"2752017","authorDomain":"agila"}

1 vote

#1 - Wed Apr 29, 2009 5:43 PM EDT

{"commentId":7043798,"authorDomain":"po-poet"}

4real?

a researcher where I worked is looking at some of the identified genes in differences to medication response. Interesting stuff coming down the pipeline

Clipped to Mental Health and Wellness

{"commentId":7043798,"threadId":"566572","contentId":"2752017","authorDomain":"po-poet"}

1 vote

#2 - Tue May 12, 2009 10:32 PM EDT

{"commentId":7096953,"authorDomain":"agila"}

agila

Thank you for the clip 4real?

a researcher where I worked is looking at some of the identified genes in differences to medication response. Interesting stuff coming down the pipeline

Any interesting development you might know of?

{"commentId":7096953,"threadId":"566572","contentId":"2752017","authorDomain":"agila"}

1 vote

#2.1 - Fri May 15, 2009 11:41 AM EDT

{"commentId":7100700,"authorDomain":"po-poet"}

4real?

Yeah she has shown that certain geneotypes respond better to atypical antipsychotics while other respond to typicals. She also correlated the difference in geneotypes to differences in f MRI (her specialty). Her sample size is small and she is still crunching data. When she publishes I will post her paper. You can google Adreinne Lahti and see some of her other work

{"commentId":7100700,"threadId":"566572","contentId":"2752017","authorDomain":"po-poet"}

1 vote

#2.2 - Fri May 15, 2009 1:40 PM EDT

{"commentId":7131706,"authorDomain":"agila"}

agila

Thank you for the information. If possible please notify me when you post the paper.

{"commentId":7131706,"threadId":"566572","contentId":"2752017","authorDomain":"agila"}

#2.3 - Sun May 17, 2009 1:24 PM EDT

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AGILA

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Altered Gene Can Increase Risk of Schizophrenia: A potential point of entry for drug therapy

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